Anatomy & Physiology
Handbook of Physiology

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Handbook of Physiology
Section 1: The Nervous System
Volume I, Parts 1 & 2: Cellular Biology of Neurons
Edited by ERIC R. KANDEL

This book is a systematic introduction to functioning of nerve cells that is designed for graduate students in neural science as well as scientists in other fields who want to learn about various aspects of neuronal functioning. With each chapter summarizing principles of important and active area of research, the volume is organized to emphasize the scope, the directions, and the excitement of modern cellular neurobiology. Advances covered here mark the beginning of an innovative period of research on the cell and on the molecular biology of individual neurons and interconnected groups of cells.

1238 pp.; 570 illus.; 8-1/2 x 11; 0-19-520658-4, Published:  1977, Price: $195.00

 Handbook of Physiology
Section 1: The Nervous System
Volume II, Parts 1 & 2: Motor Control
Edited by VERNON B. BROOKS

In this interdisciplinary view of the control of posture and movement, the authors have summarized concepts, facts, and methods of current research, bridging physiology, anatomy, the behavioral sciences, control theory, and related areas. The overall emphasis is on how the individual deals with an environment that dictates the dimensions of both motor efforts and their controls. Topics begin with peripheral conditions and events, move on through unconscious adjustments, proceed to voluntary, conscious adjustments, and conclude with an analysis of behavioral motor performance.

"This publication comes very close to perfection, above all in the way of compiling information, also in the way of presentation and interpretation of it in a particular area." --Rehabilitation

"These volumes are not only a pleasure to read but contain a wealth of information and ideas. They can be warmly recommended to anyone wishing for a comprehensive account of the state of knowledge and the direction of current research in the field of motor control." --Brain

"A stellar collection of magisterial papers that most neuroscientists will want and that every library will need." --The New England Journal of Medicine

1548 pp.; 732 illus.; 8-1/2 x 11; 0-19-520659-2, Published:  1981, Price: $258.00

Handbook of Physiology
Section 1: The Nervous System
Volume III, Parts 1 & 2: Sensory Processes
Edited by IAN DARIAN-SMITH

A comprehensive, balanced account of the neural mechanisms that allow us to sense the world around us, this volume surveys advances made since the 1959-60 publication of the first edition of the Handbook volumes on the nervous system. After an outline of the historical perspectives of sensory research, the text considers the measurement of sensory performance in man and experimental animals, the structural organization of sensory systems, and the neural bases of vision, hearing, somatic sensibility, and the chemical senses. Included are chapters on the perception of the body in space and the functional asymmetry of the human cerebrum.

"A lasting testimonial to the immense labour of its preparation as well as a valuable synthesis of knowledge of sensory mechanisms . . . Our full thanks are due to all participants in its genesis: authors, editors and publishers." --Brain

"The most comprehensive review of the current state of knowledge . . . It should be part of every college library and on the bookshelf of every researcher and teacher of sensory physiology." --Journal of Manipulative and Physiological Therapeutics

"The editor has done an excellent job of selecting the authors and organizing the book . . . . For the teacher, researcher, and advanced student, this volume is valuable as an introduction . . . It contains, in addition, a superb introductory chapter by Richard Jung." --American Scientist

1244 pp.; 636 illus.; 8-1/2 x 11; 0-19-520660-6, Published:  1984, Price: $289.00

Handbook of Physiology
Section 1: The Nervous System
Volume IV: Intrinsic Regulatory Systems of the Brain
Edited by FLOYD E. BLOOM, Scripps Clinical Research Institute

An in-depth examination of those components in the brain's reticular core that provide the general mechanisms for integration. This volume offers a dramatic contrast and comparison between the highly precise and specific structures and functions of the motor and sensory systems described in Volume II (Motor Control, 2 volumes, edited by Vernon B. Brooks) and Volume III (Sensory Processes, 2 volumes, edited by Ian Darian-Smith), and the more divergent structures and less functionally constrained effects of the systems of the reticular core. The text proceeds from studies of synaptic transmitter mechanisms in the central and peripheral nervous systems to studies of specific, chemically defined anatomic systems that incorporate these mechanisms and divergent structures into a regulatory ensemble process.

"This book and others in this series will be a place--the place--to start. All the chapters are comprehensive and detailed in their coverage, and most give an excellent account of the history of their topic. . . A reference volume of formidable proportions. It provides as up-to-date an account of modern, integrative neurophysiology as could reasonable be sought, and will take the serious student to the forefront of knowledge." --The Medical Journal of Australia
850 pp.; 371 illus.; 8-1/2 x 11; 0-19-520661-4, Published:  1986, Price: $272.00 

Handbook of Physiology
Section 1: The Nervous System
Volume V, Parts 1 & 2: Higher Functions of the Brain
Edited by FRED PLUM, Cornell Medical Center

This volume reviews the mechanisms underlying psychology and behavior in animals and humans, and examines the field comprehensively from a physiological standpoint. After an introductory chapter that briefly traces the history of neuroscientific thought and describes its social implications, 21 substantive essays survey such topics as learning and memory in nonmammalian and simple systems, mechanisms of emotion and attention, mechanisms of perception, and human disease and higher brain function. This work describes a vast portion of the recent extraordinary advances in understanding the physiology of mammalian behavior and the mechanisms by which disease or damage in the human brain affects the highest intellectual and behavioral faculties.
964 pp.; 367 illus.; 8-1/2 x 11; 0-19-520662-2, Published:  1987, Price: $341.00

Handbook of Physiology
Section 2: The Cardiovascular System
Volume I: The Heart
Edited by ROBERT M. BERNE
Associate Editor: NICK SPERELAKIS

Designed to be useful to students of physiology at all stages of study--and to professional physiologists and interested scientists in related disciplines--this authoritative reference work offers 25 chapters in seven sections that fully elucidate normal cardiac function. Among the topics discussed are development and morphology of the heart, electrophysiology, cardiac contraction, and myocardial blood supply.

"In the best tradition of handbooks, this volume provides authoritative, well-documented and critical overviews of cardiac structure and function . . . Each chapter is amply and clearly illustrated . . . This book will be a most valuable reference for the cardiovascular scientist and teacher and for the clinical investigator. It will also make rewarding reading for the advanced student of cardiovascular physiology." --The New England Journal of Medicine

"Many of the chapters are among the best available in any language . . . This book and its companion volumes chronicle information that is exciting, complex, and infinitely humbling." --Journal of the American Medical Association

848 pp.; 11 color illus, 383 b/w halftones & line illus; 8-1/2 x 11; 0-19-509886-2, Published:  2001, Price: $199.00
Replaces the 1979 publication: 978 pp.; 612 illus.; 8-1/2 x 11; 0-19-520663-0

Handbook of Physiology
Section 2: The Cardiovascular System
Volume II: Vascular Smooth Muscle
Edited by DAVID F. BOHR, ANDREW P. SOMLYO, and HARVEY V. SPARKS, Jr.

A comprehensive review of the structure, chemistry, and function of vascular smooth muscle, this volume reflects the extensive research by cardiovascular physiologists on the contractile system in the blood vessel wall. Six sections cover these important topics: Structure, Electrolyte and Electrophysiology; Regulation, Biochemistry, Muscle Mechanics, and Phylogenetic Variations.

"Serious students will welcome this volume because of the astronomical amount of material covered in its text. All in all, this is a magnificent volume for the connoisseur."--Practical Cardiology

694 pp.; 331 illus.; 8-1/2 x 11; 0-19-520664-9, Published:  1980, Price: $116.00

Handbook of Physiology
Section 2: The Cardiovascular System
Volume III, Parts 1 & 2: Peripheral Circulation and Organ Blood Flow
Edited by JOHN T. SHEPHERD and FRANÇOIS M. ABBOUD

Published in two parts to cover the many advances in the field, this work updates a 1963 Handbook of Physiology volume dealing with the regulation of the circulation to the lungs and the systemic vascular beds. The contributors are experts in their fields who share extensive experience and broad perspectives. This is an important body of knowledge and viewpoints that will be referred to for years to come.

"Together, these two books on the cardiovascular system represent a thorough overall review of peripheral circulatory control. This volume is an essential publication for research workers in this field and it can also be very valuable as a reference text for the clinician." --Critical Care Medicine

1143 pp.; 570 illus.; 8-1/2 x 11; 0-19-520665-7, Published:  1983, Price: $257.00

Handbook of Physiology
Section 2: The Cardiovascular System
Volume IV, Parts 1 & 2: Microcirculation
Edited by EUGENE M. RENKIN and C. CHARLES MICHEL

This two-volume work provides a consolidation of essential concepts and developments within microvascular physiology. Each chapter introduces the scope and principles of its topic and offers more experienced investigators a critical assessment of key ideas and techniques. The approach integrates contemporary and classical thought, outlining the development of microcirculation theory from the earliest observations. The discoveries of bioengineers and mathematically oriented biologists in the 1960s are traced, and authors discuss the valuable and continuing advances that have come from electron microscopy. They also focus on the recent upsurge of interest in the cellular biology of endothelium. In reviewing these and other contributions, this work provides a comprehensive, in-depth compendium of current knowledge.

"This volume, like the others in the Handbook, is well produced, carefully proofread, generally well illustrated, and published on high-quality paper....The chapters achieve the goal of collecting in one place an encyclopedic compilation of knowledge about almost all aspects of the microcirculation and a very extensive list of references."--The New England Journal of Medicine

"Overall, these books give a fundamental insight into the area of cardiovascular physiology and highlight the interdisciplinary nature of the methods brought to bear on the investigation and analysis of the microcirculation. These books should prove to be an invaluable reference for the specialist."--Chest

"This skillfully written volume on microcirculation succeeds in presenting an extensive and detailed analysis...The critical descriptions of the various subjects addressed correspond in scope and scholastic excellence to material in previous publications by the American Physiological Society....Should be read by scientists who wish to acquire further information in this rapidly developing area of physiology. Because of the inclusion of an extensive objective analysis of the state of the art of research in microcirculation, this book should also be a useful reference source for physicians in general."--Mayo Clinic Proceedings

1124 pp.; 631 illus.; 8-1/2 x 11; 0-19-520666-5, Published:  1984, Price: $289.00

Handbook of Physiology
Section 3: The Respiratory System
Volume II, Parts 1 & 2: Control of Breathing
Edited by NEIL S. CHERNIACK, Case Western Reserve University, and JOHN G. WIDDICOMBE, St. George's Hospital Medical School, London

This volume reflects today's unprecedented awareness of the interrelationship among different physiological regulatory systems and encompasses the diverse topics that must be considered in any study of respiratory control. Part 1 explores central nervous system control of breathing and the intimate relationships to afferent inputs and motor pathways. Major chapters review the constant interaction between voluntary and involuntary actions that shapes the characteristics of the breathing cycle; examine levels of control within the CNS; and detail the dynamic and adaptive aspects of central respiratory control. Part 2 reviews the interplay between respiratory regulation and regulatory mechanisms in other physiological systems. A separate section reviews the comparative physiology of respiratory control, thus demonstrating further adaptive characteristics and tight linkage to other regulatory mechanisms.

"This volume reflects not only the growth of information but also an improved organization and an expanded range of topics within the handbook series . . . This is the literature, and it is summarized by many of its most prominent contributors . . . The volume is highly recommended." --American Scientist

972 pp.; 385 illus.; 8-1/2 x 11; 0-19-520668-1, Published:  1986, Price: $258.00 

Handbook of Physiology
Section 3: The Respiratory System
Volume III, Parts 1 & 2: Mechanics of Breathing
Edited by PETER T. MACKLEM, Royal Victoria Hospital, Quebec, Canada, and JERE MEAD, Harvard School of Public Health

The contributors to Mechanics of Breathing approach this complex physiological subject from the perspective of every relevant field: medicine, anatomy, physiology, engineering, acoustics, physics, mathematics, surface chemistry, immunology, cellular biology, neurophysiology, and psychology. Their aim is not only to provide the most intensive examination available of the subject but also to facilitate communication among varied disciplines. Much recent information about respiratory mechanics is included, making this the most useful reference on a rapidly evolving subject.

"Clearly a formidable text, of broad perspective and high scholarship. But it is one which has much to offer students of pulmonary mechanics at all levels....It is by any criteria of critical scrutiny a highly commendable text and one which is likely to remain the standard of excellence in the field for a long time to come."--Chest

"Each chapter can stand alone as an up-to-date review....A necessity for researchers and specialists in the area of pulmonary disease."--Physical Therapy

834 pp.; 407 illus.; 8-1/2 x 11; 0-19-520669-X, Published:  1986, Price: $257.00

Handbook of Physiology
Section 3: The Respiratory System
Volume IV: Gas Exchange
Edited by LEON E. FARHI, SUNY Buffalo, and S. MARSH TENNEY, Dartmouth Medical School

This fourth and last volume of the Handbook of Physiology section on the respiratory system deals with the ultimate goal of the system: gas exchange. To fulfill this role the lungs cyclically expand and contract and the alveoli are perfused. The regulatory function is geared to optimize the exchange of oxygen and carbon dioxide. Like other areas of respiratory physiology, the study of gas exchange has made giant strides since the first edition of the Handbook was published. Though much of what was written then remains important and has served as a basis for more recent developments, this edition also extends into the newer fields of respiratory biology. The broader sweep is exemplified by topics that had no previous counterparts: development and growth of the lungs, pulmonary circulation, pulmonary metabolism, and pulmonary defense mechanisms. Among the familiar topics that are delved into more deeply in this edition are lung volumes and ventilation, mechanical properties of the lungs and thorax, control of breathing, and respiratory gas exchange. The text follows the normal sequence of topics, from the description of basic physical principles to their application under normal and unusual conditions.

"Blending current theoretical understanding with the most recent experimental data, this publication . . . will serve as a guide to new concepts, techniques, and directions of future development in studies of normal and impaired pulmonary gas exchange." --Progress in Respiration Research

"The APS Handbooks are scientific mountains--the best that can be done, often by authors who are clearly the best candidates in the world to write on particular topics." --The Quarterly Review of Biology

480 pp.; 201 illus.; 8-1/2 x 11; 0-19-520670-3, Published:  1987, Price: $175.00

Handbook of Physiology
Section 4: Environmental Physiology
Two Volume Set
Edited by MELVIN J. FREGLY, University of Florida, and CLARK M. BLATTEIS, University of Tennessee

Thirty years have passed since the last edition of this volume was published. Since then, many advances have occurred in the field of environmental physiology. Established areas of research have been expanded by the application of new concepts and the use of more modern tools, while other areas, then in their infancy, have developed into important subjects of current research. The latter include, for example, research in the physiological adaptations and acclimations to underwater and space environments, to microorganisms responsible for acute inflammatory diseases, and to psychosocial stress. All of the chapters in this book were written by international investigators noted for their individual contributions to the areas that they cover. The focus of their presentations addresses the regulatory mechanisms of the physiological responses to the many factors constituting the external environment. Each contribution has been subjected to a rigorous review process in order to ensure its relevance and timeliness. At the same time, innovative and even controversial interpretations were not rejected, so that the material in this volume represents the most up-to-date understanding of, and debate over, the physiological adaptation to the environment.

1626 pp.; 463 b/w & 1 color illus; 8-1/2 x 11; 0-19-507492-0, Published:  1996, Price: $310.00

Handbook of Physiology
Section 6: The Gastrointestinal System
Volume I: Motility and Circulation, Parts 1 & 2
Section Editor: STANLEY G. SCHULTZ, University of Texas, Houston
Volume Editor: JACKIE D. WOOD, Ohio State University, Columbus, Ohio

Since the publication of the first volume on gastrointestinal motility in the Handbook of Physiology (1968), there has been an impressive development of new information, new methods and new understanding of motility. These advances span all levels of organization from single smooth muscle cells and neurons to integrated organ function,and they are expertly documented by the authors of this edition. Parallel progress in understanding the vascular system and lympthatics of the alimentary canal over the past 20 years is reviewed in equal detail. Among the topics given authoritative coverage are the ultrastructure of gastrointestinal smooth muscle, the extracellular matrix, and the mechanical properties of the musculature; electrical and chemical behavior of gut neurons and the immunocytochemical localization of neurotransmitters; the unique pattern of motility in the interdigestive state; measurement of intraluminal pressures and electrical and contractile activity at all levels of the gastrointestinal tract; abnormalities associated with parasitic infections; enterotoxins, emesis and surgical perturbations that shed light on normal mechanisms; the basic structure and ultrastructure of the gut vasculature; regional hemodynamics and regulation of the digestive circulation; and neuromuscular transmission in the gut musculature and its neurohormonal control. Overall, the book provides an unparalleled view of gastrointestinal motor and circulatory function. It will be of great use to a wide spectrum of readers, including physiologists, gastroenterologists, graduate students, and postdoctoral fellows.

1906 pp.; 840 illus.; 8-1/2 x 11; 0-19-520791-2, Published:  1989, Price: $310.00

Handbook of Physiology
Section 6: The Gastrointestinal System
Volume II: Neural and Endocrine Biology
Volume Editor: GABRIEL M. MAKHLOUF, Medical College of Virginia
Section Editor: STANLEY G. SCHULTZ, University of Texas, Houston

This volume marks the coming of age of knowledge concerning the neural and endocrine biology of the gut. It is the first volume in the Handbook of Physiology to be devoted entirely to this field. It is also the very first volume ever published that deals systematically with the biochemistry, cell biology, molecular biology, pharmacology, and physiology of hormonal and neural peptides of the gut. Written by some forty recognized experts, Neural and Endocrine Biology details the discoveries of a field that is now just twenty-five years old. The early chapters address general topics and provide a broad overview of the field, including information on immunocytochemistry of endocrine cells and enteric neurons and the physiological significance of hormonal, paracrine, and neural peptides. Fourteen of the volume's twenty-eight chapters are devoted to individual hormonal and neural peptides--their distribution, pharmacology, and physiological and cellular functions. The final chapter offers an overview of recently discovered peptides, including pancreastatin and two neural peptides, galanin and calcitonin gene-related peptide (CGRP). Neural and Endocrine Biology will be a welcome new resource for graduate students, instructors, and active researchers and clinicians who need a complete, up-to-date reference in regulatory peptides and gastrointestinal physiology and pharmacology.

736 pp.; 334 illus.; 8 1/2 x 11; 0-19-520795-5, Published:  1989, Price: $205.00

Handbook of Physiology
Section 6: The Gastrointestinal System
Volume III: Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion
Edited by JOHN G. FORTE, University of California, Berkeley, and STANLEY G. SCHULTZ, University of Texas, Houston
Volume Editor: JOHN G. FORTE

The third volume in The Gastrointestinal System reflects the expansion of knowledge of the cell physiology of secretion. Each chapter, grouped by traditional anatomical location, was written emphasizing the cellular bases of secretion and includes a review of the broader as well as the more integrative aspects of secretion.
788 pp.; 365 illus.; 8 1/2 x 11; 0-19-520816-1, Published:  1989, Price: $205.00

Handbook of Physiology
Section 6: The Gastrointestinal System
Volume IV: Intestinal Absorption and Secretion
Section Editor: STANLEY G. SCHULTZ, University of Texas, Houston
Volume Editors: MICHAEL FIELD, Columbia University College of Physicians and Surgeons, and RAYMOND A. FRIZZELL, University of Alabama, Birmingham
Executive Editor: BRENDA B. RAUNER

Here is a thorough, up-to-date survey of the physiological processes through which salt, water, and nutrients are absorbed or secreted by the intestinal tract, and of how these myriad processes are regulated. In twenty-five chapters, written by a team of leading experts, the volume addresses four main topics: the methodologies and basic principles of structure and function; intestinal ion transport; nutrient absorption; and macromolecular transport. Throughout, the contributors emphasize recent developments in the field--for example, neuroendocrine-immune cell interactions in the intestinal mucosa, the regulation of intestinal sodium transport, the cloning of the intestinal glucose carrier, the intestinal cytoskeleton, and the regulation of intestinal epithelial transport function by protein kinases and calmodulin. This is not only the fourth and final volume in the series; it is also the broadest, most contemporary approach to this important topic. As such, this book will be warmly welcomed--and often consulted--by student, scholars, professionals, and anyone researching intestinal absorptive mechanisms and their regulation.

672 pp.; illus.; 8-1/2 x 11; 0-19-520817-X, Published:  1991, Price: $205.00

Handbook of Physiology
Section 7: The Endocrine System
Volume I: Cellular Endocrinology
Volume Editor: P. MICHAEL CONN and Section Editor: H. MAURICE GOODMAN

With the many new techniques available in cellular and molecular biology, it has been possible to identify common patterns of activity in cells of the endocrine system. This volume provides and in-depth and up-to-date view of progress in cellular and molecular endocrinology. It deals with the conceptual fundamentals of receptor identification and structure, gene expression, signaling, and second messenger systems. It also describes newly-appreciated concepts of receptor and gene regulation, and covers physiological processes such as secretion, steroidogenesis, and apoptosis. The chapters are written by international authorities who are well-recognized for their contributions to the field of endocrinology. Combining physiology and molecular biology, the book will be of value to all basic endocrinologists and to clinicians interested in the underlying regulation of endocrine systems.
P. Michael Conn is Professor and Director of the Laboratory of Neuroendocrinology at Rockefeller University.

616 pp.; 161 halftones and linecuts; 8-1/2 x 11; 0-19-510935-X, Published:  1998, Price: $174.00

Handbook of Physiology
Section 7: The Endocrine System
Volume II: The Endocrine Pancreas and Regulation of Metabolism

Edited by LEONARD S. JEFFERSON, Pennsylvania State University College of Medicine, and ALAN D. CHERRINGTON, Vanderbilt University Medical School

This reference work provides a comprehensive and up-to-date review of hormonal regulation of metabolism. Following a general introduction by Sir Philip Randle, the book is divided into four sections:1. The Islets of Langerhans, 2. Target Tissues for Metabolic Regulatory Hormones, 3. Influence of Hormones Acting as Acute Metabolic Regulators on the Actions of Islet Hormones, and 4. Integrated Hormonal Responses to Physiological Challenges. The fourth part covers many interesting conditions such as pregnancy, aging, obesity, hypoglycemia, insulin-dependent diabetes mellitus, and starvation.

660 pp.; 20 halftones, & 336 line illus; 8-1/2 x 11; 0-19-511326-8, Published:  March 2001, Price: $295.00

Handbook of Physiology
Section 7: The Endocrine System
Volume III: Endocrine Regulation of Water & Electrolyte Balance
Edited by JOHN C. S. FRAY, University of Massachusetts, Medical Center

This volume takes an integrative approach to the physiologic process of water and electrolyte balance. It is devided into three parts: sodium and potassium balance, hormones regulating electrolyte balance, and endocrine regulation of calcium and phosphate balance. Renin, angiotensinogen, angiotensin converting enzymes, angiotensins, aldosterone, kallikrein-kinin, natriuretic hormones, antidiuretic hormone, parathyroid hormone and polyhormones, parathuroid hormone-related peptide and vitamin D are discurssed in critical and comprehensive detail. The book presents the genomic alterations in electrolyte and water balance as functional processes and thereby helps lay the foundation for the emerging era of functional genomics in both health and disease.

New and recent titles of related interest:
752 pp.; 16 halftones, & 151 line illus; 8-1/2 x 11; 0-19-511044-7, Published:  1999, Price: $237.00

Handbook of Physiology
Section 7: The Endocrine System
Volume IV: Coping with the Environment: Neural and Endocrine Mechanisms
Edited by BRUCE S. MCEWEN, The Rockefeller University

This unique volume provides fresh insights into the neuroendocrine systems that enable individuals to cope with their physical and social environments. Since the pioneering work of Claude Bernard and Walter Cannon on homeostasis and Hans Selye and John Mason on stress, there have been profound advances in biomedicine, and the regulation of gene expression has emerged as a major theme in connecting nature with nuture. With this has come an appreciation of the long time frame in which the environment produces both adaptive and maladaptive changes in an individual organism during the lifespan. Indeed, experiences early in life can have a life-long impact, and advances in behavioral and social sciences have interfaced with biology to reveal that the psychosocial environment shapes life-long patterns of neuroendocrine function and behavior, thus influencing physical and mental health. This book begins by discussing the two main stress mediators, the catecholamines and the hypothalamic-pituitary-adrenal axis. It then deals with the neurobiology of fear, stress and coping and with biological aspects of stress and coping during the life course. Next it considers diurnal rhythms, sleep and immune defense mechanisms. Finally it discusses stress and coping in the social environment in both animal models and humans. The book should provide an intellectual framework for further integration of social, psychological, and biological sciences around basic concepts in physiology.

574 pp.; 96 halftones & line illus; 8-1/2 x 11; 0-19-511252-0, Published:  2000, Price: $150.00

Handbook of Physiology
Section 7: The Endocrine System
Volume V: Hormonal Control of Growth
Edited by JACK L. KOSTYO, University of Michigan Medical School, and H. MAURICE GOODMAN, University of Massachusettes Medical Center, Worcester, MA

This is a new addition to the acclaimed Handbooks of Physiology series, which Oxford publishes together with the American Physiological Society. The Endocrine System is an original book providing a state-of-the-art, scholarly and comprehensive picture of the endocrine regulation of growth. The emphasis is on the growth hormone--its structure, genetics, secretion, receptors and actions--but insulin, insulin-like growth factors and thyroid hormones are also covered in detail. The volume contains as much molecular endocrinology as physiology.
856 pp.; 17 fullcolor, 32 halftones, 167 line illus; 8-1/2 x 11; 0-19-511305-5, Published:  1999, Price: $190.00

Handbook of Physiology
Section 8: Renal Physiology
Edited by JACK ORLOFF and ROBERT W. BERLINER

This important volume provides a cogent analysis of basic principles. The chapters on anatomy of the kidney focus on ultrastructure, providing a basis for understanding the following descriptions of transport across membranes and through intercellular channels. The discussion of investigative techniques begins with an assessment of clearance methods in animals and continues with an analysis of the techniques of stop flow, micropuncture, and in vitro perfusion of isolated tubule segments. Acidification and ammonia excretion are presented in depth, as are discrete tubular transport processes and electrophysiology. Other topics include glomerular-tubular balance, the role of aldosterone in electrolyte transport of antidiuretic hormone on water movement, and seminal views by key investigators on blood flow and filtration. Comparative physiology is also discussed, along with the renin-angiotensin system, the physiology of diuretic agents, and even the conduit system out of the kidney proper.

1090 pp.; 545 illus.; 8-1/2 x 11; 0-19-520683-5, Published:  1973, Price: $137.00

Handbook of Physiology
Section 8: Renal Physiology
Volumes I and II
Edited by ERICH E. WINDHAGER, Cornell University Medical Center

This new section of the Handbook of Physiology provides a comprehensive and authoritative account of current knowledge about kidney function. The early chapters emphasize structure, and relationships between structure and function. Tissue culture and renal micropuncture are among the many techniques discussed in detail. The physiology of non-renal tissues that serve as models of tubule function, comparative physiology, and developmental aspects of kidney function are similarly discussed. Glomerular filtration and mechanisms of transport of different solutes in water at the level of plasma membranes, of renal tubules, and of the whole kidney are covered in depth. The concentrating mechanism, the regulation of kidney function, including its relation to blood pressure homeostasis, and kidney-bone interactions are also reviewed in detail. Chapters on the biochemistry and metabolism of the kidney, diuretics, and erythropoietin round off the discussion. These two volumes offer the most up-to-date, comprehensive and authoritative coverage of kidney function available. Ninety international authorities present modern concepts of renal function, including the biochemistry, cell biology, and morphology of the kidney. Experimental techniques to study renal function are given detailed treatment. The chapters span the entire range of knowledge about kidney function, from the level of the plasma membrane to whole organ function, regulation and integration of kidney function into whole body homeostasis.
2544 pp.; 719 illus.; 8-1/2 x 11; 0-19-506006-7, Published:  1992, Price: $415.00

Handbook of Physiology
Section 9: Reactions to Environmental Agents
Section Editor: DOUGLAS H. K. LEE
Associate Editors: HANS L. FALK and SHELDON D. MURPHY

This section emphasizes well-known environmental perturbations, particularly those introduced by physical and chemical agents. It will be of interest to a wide variety of scientists working in industry, engineering, food science, and the laboratory. Among the topics examined are response to physical agents; nature, origin, and distribution of chemical agents; reactions and determinants at portal of entry; transportation and transformation of chemical agents; distribution and excretion of chemical agents; and mechanisms of cellular injury.

"Serves as an excellent tool for occupational and environmental health scientists involved in the task of defining and identifying the potential risks associated with new environmental and occupational hazards. I would also encourage its use as a test or at least reference material for courses in physiology." --Environmental International

667 pp.; 234 illus.; 8-1/2 x 11; 0-19-520684-3, Published:  1977, Price: $105.00

Handbook of Physiology
Section 10: Skeletal Muscle
Edited by LEE D. PEACHY
Series Editor: RICHARD H. ADRIAN

In this integrated view of research and possible future developments in muscle research, an authoritative group of contributors discusses structure, contraction, excitation-contraction coupling, specialization, adaptation, and disease. Muscle research is charted from the molecular and cellular level to that of the whole organism.

"This is a handsome book, very well printed and illustrated . . . There is little doubt this handbook should be available in institutions doing research on muscle." --The Medical Post

700 pp.; 333 illus.; 8-1/2 x 11; 0-19-520685-1, Published:  1983, Price: $153.00

Handbook of Physiology
Section 11: Aging
Edited by EDWARD J. MASORO, University of Texas, San Antonio

The aims of this new section of the Handbook of Physiology are two. One is to present a source of basic knowledge about aging including research approaches for use by physiologists as well as other biologists not directly involved in aging research. The other is to provide comprehensive information for gerontologists on the physiological characteristics of aging in mammals, particularly humans. The principles of biological gerontology are presented in Part I, which includes discussions of approaches to the measurement of the rate of aging of populations, the difficulty of assessing aging of the individual, theoretical concepts regarding the nature of aging, and conceptual issues concerning the relationship between aging and disease. Methodological issues unique to aging research are presented in Part II. The focus is on study design and analysis and on cell culture models, animal models and human subject use. Part III provides a detailed description of the cellular and noncellular aspects of aging. This part also discusses the metabolic characteristics of aging. In Part IV, twelve chapters provide comprehensive coverage of the influence of age on the physiology of the nervous systems and the organism. Interventions of aging processes, proposed and established, are the subject of Part V.

"Is far more than an encyclopedia of senescence in traditionally defined physiological systems. It is also a comprehensive manual for the critical design and evaluation of research in a discipline with unique and often subtle pitfalls....Because of the high quality of the articles, and the juxtaposition of nontraditional with traditional topics. new researchers, students and educators should find this book excellent both as an introduction to the current state of knowledge in the field as a guide for the evaluation of current theory and new research."Experimental Gerontology

"The book brings together information on a variety of topics in the field of gerontology. It is a useful book for beginning researchers who need quick access to information on an aspect of aging which is not their specialty."--S.Kaleen Quadri, M.D., University of Kansas Medical Center

"A useful reference volume that presents much...of the key knowledge in the physiology of aging."--The Physiologist

696 pp.; 152 illus.; 8-1/2 x 11; 0-19-507722-9, Published:  1995, Price: $205.00

Handbook of Physiology
Section 12: Exercise: Regulation and Integration of Multiple Systems
Edited by LORING B. ROWELL, University of Washington, and JOHN T. SHEPHERD, Mayo Clinic and Foundation

This is the first section of the Handbook of Physiology to deal exclusively with exercise. It is also the first single volume to analyze in-depth the regulation and integration of motor, respiratory, cardiovascular and metabolic systems over the broad range of functions demanded by excercise. Its systematic examination of the regulation of these four systems draws from every area of physiology as well as from pharmacology, biochemistry, cellular and molecular biology and medicine. It highlights excercise as a uniquely powerful means of exploring the integrative aspects of whole body function.

One feature of this volume is its in-depth analysis of the regulatory mechanisms responsible for the close matching of motor, respiratory, cardiovascular, and metabolic control during exercise. By combining studies of control at cellular and molecular levels with studies on whole animals, this Handbook provides the natural and logical integration that is a hallmark of physiology--and is also what lures many scientists to the study of exercise.

The internationally recognized authors provide a critical analysis of the mechanisms that govern control of movement, breathing, pulmonary gas exchange, blood flow and blood pressure, and skeletal muscle metabolism. They examine both functional and structural limits to the performance of organ systems under severe stress and show how these limits can be altered by age and physical conditioning. In some cases this required treatment of topics that have not been reviewed before such as how the heart interacts mechanically with the pericardium, lung, and chest wall to alter central hemodynamics.

This volume offers a unique synthesis of fresh information and ideas about the physiology of exercise that will provide a basis for future investigations in this field. It sets a new standard for the physiological study of exercise and will be of keen interest and lasting value to physiologists, sports scientists, kinesiologists, cardiologists, motor control neurologists, and physicians.

1224 pp.; 418 illus.; 8-1/2 x 11; 0-19-509174-4, Published:  1996, Price: $205.00

Handbook of Physiology
Section 13: Comparative Physiology
Two-Volume Set
Edited by WILLIAM H. DANTZLER, University of Arizona, Tucson

This handbook of comparative physiology brings together for the first time in a single volume a review of the entire field at the advanced level appropriate for research scientists, graduate students, postdoctoral fellows, and faculty. It begins with a chapter on adaptation and the evolution of of physiological characters. After that introduction, it is organized to provide a complete survey of comparative physiology for both vertebrates and invertebrates, with up-to-date chapters on each of the organ systems. The chapter authors have not only reviewed the relevant material, but have also placed it into an appropriate perspective for the reader. Following these chapters, the book addresses comparative physiological strategies for dealing many environmental problems such as exterme temperatures, extreme dryness, seasonal and diurnal cycles, and variations in salinity and osmolality of aqueous environments. Thus the book provides a comprehensive review of the differing physiological strategies employed by vertebrates and invertebrate species to deal with common problems.

1856 pp.; 629 illustrations; 8-1/2 x 11; 0-19-507419-X, Published:  1997, Price: $325.00

Handbook of Physiology
Section 14: Cell Physiology
Edited by JOSEPH F. HOFFMAN, Yale University, School of Medicine, and JAMES D. JAMIESON, Yale University, School of Medicine

The aim of this Handbook is to survey the foundations and current status of key areas in modern cellular and molecular physiology. The topics covered range from the most fundamental biophysical and biochemical bases of cellular physiology to more concerted cellular biological processes. A more elusive goal of this volume is to provide a framework for future research linking these various processes with their integrative aspects in whole animal systems.

The chapters begin with basic membrane processes that include membrane structure as it relates to function, the biophysics of membrane transport, and cell volume regulatory mechanisms. Then the organization and function of the plasma membrane and intracellular organelles involved in membrane trafficking and the biogenesis of cell polarity are reviewed in depth. Energy generation and transduction that subserve cellular function are covered in another series of chapters. The structure and function of the cytoskeleton and its relationship to events regulated by interaction with the extracellular matrix are examined in detail. Chapters on integrative aspects of cellular physiology including immunobiology, cell-cell interactions, fertilizaton, and interactions of cells with the extracellular matrix round out the authoritative survey of contemporary cellular physiology in the Handbook. Researchers, teachers, and graduate students will find it a uniquely useful resource.

982 pp.; 42 halftones, 286 line drawings; 8-1/2 x 11; 0-19-507172-7, Published:  1997, Price: $205.00

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