| Home --- Professional Books --- Medical Sciences-- Pharmacology |
| Please direct all inquiries to: orders@leabooks.com |
Pharmacology
Oxford University Press
IMPORTANT
NOTICE:
All
prices are subject to change. The prices listed here are for
reference only and were the publisher's suggested retail price at
the time we posted this catalogue. Usually, LEA Book Distributors
will charge the publisher's suggested US retail price or at times
the publisher's price for foreign customers. Check with us for
latest price changes.
Pharmacology
in the Practice of Anaesthesia
Edited by LEON KAUFMAN, University College Hospital and St
Mark's Hospital, London, and PETER V. TABERNER, University of
Bristol School of Medical Sciences, UK
Pharmacology in
the Practice of Anaesthesia outlines, in a highly-accessible
manner, the principles of pharmacology as
applied to anaesthesia and intensive care. Anaesthetists are
expected to know not only the pharmacology of
anaesthetic agents, but also the pharmacology of
drugs used in medical disorders and the possibility of drug
interactions and side effects. The book contains introductory
chapters covering the principles which affect the mode of action
of the drug. These are followed by detailed descriptions of
anaesthetic agents and the drugs affecting each body system.
Relevant physiology is included to make the pharmacology
more comprehensible, and key points are highlighted throughout
the text.
The two applied sciences fundamental to anaesthesia are physiology and pharmacology. All trainees need to acquire a thorough grounding in the principles of pharmacology and their application in practice, and pharmacology thus forms a major part of postgraduate examinations, including the Fellowship exams in the UK, and Boards in the Us. This is an up-to-date textbook for trainees in anaesthesia which will also see them through many years of clinical practice.
The authorship involves the unique, active
collaboration between pharmacologists and clinical anaesthetists.
Leon Kaufman is a well-known FFA examiner, and the many
contributors are lecturers or consultants in anaesthesia or
clinical pharmacology.
704 pp.; 203 linecuts; 0-340-55171-2; 1996
Price: $135.00 (05)
Ion Channel Pharmacology
Edited by BERNAT SORIA and VALENTÍN CEŃA, both at the
Institute of Bioengineering and Neurosciences, Universidad Miguel
Hernández, Spain
The pharmacology of ion channels is
becoming increasingly important. Molecular biology techniques
have led to the better understanding of ion channel structure
which has opened the way for the development of new drugs
targeted at specific types of ion channels. This volume provides
a fully comprehensive, single-volume overview of the effects of
different drugs and toxins on ionic channels. The first part of
the book deals with the development of ion channels. Subsequent
chapters offer detailed descriptions of the electrophysiological
properties and pharmacology of eight different types of ion
channels, including material on intracellular, cyclic
nucleotide-gated, and receptor operated channels. For each
channel type, the effects of different drugs in various cell
types are discussed, along with the potential roles of channels
in therapeutics. Clearly written, Ion Channel Pharmacology
will be an essential reference tool for all researchers in this
topical and fast-growing subject area.
Price: $159.50 (05) , 1998 ISBN: 0198523602
Principles of Medical Pharmacology
Sixth Edition
Edited by HAROLD KALANT and WALTER H. E. ROSCHLAU, both at
University of Toronto
The Sixth Edition of a this widely popular
book has been extensively revised, enlarged and updated to
reflect the latest research. The volume covers all aspects of
medical pharmacology, including a comprehensive
discussion of the clinically important features of
pharmacokinetics. It also provides a detailed treatment of topics
that are often given less attention in similar texts, such as
drug abuse and dependence, behavioral pharmacology,
drug interactions, neonatal and geriatric pharmacology,
and new drug development.
This new edition features a number of
improvements over its predecessors. Each chapter in the systems
sections now begins with a brief case history that is meant to
stimulate the reader's interest by demonstrating the clinical
relevance of basic pharmacology. New overview
chapters and sections have been added on second messenger
systems, and on the functional organization of the nervous,
cardiovascular, gastrointestinal, and immune systems. The chapter
on antiparasitic agents has been expanded to include organisms
and drugs with relevance to many parts of the world. Extensive
sections on current chemotherapy of HIV infection and AIDS along
with discussions of new agents for drug-resistant tuberculosis,
malaria and cancer; inflammatory bowel disease; and genetics of
drug metabolism appear for the first time in the Sixth Edition.
Due attention has been paid to new drugs being tested in North
America and Europe that will probably be on the market soon.
Praise for previous editions:
"An excellent textbook...The illustrations are simple and
easy to comprehend."--James W. Fisher, Chairman, Department
of Pharmacology, Tulane
University
"The authors and the editors have done a superlative job
of writing and revision. I like the new format and printing
style, and I am particularly impressed with the redrawn
illustrations."--D.R.H. Gourley, Chairman, Department of Pharmacology,
Eastern Virginia Medical School
"An easily read, inclusive, well illustrated, well
organized, and up-to-date introductory text....The figures are
illustrative, well presented and informative. The tables are
clear and accurate."--American Journal of
Pharmaceutical Education
"Many aspects of this book are noteworthy. The overall
organization is coherent and logical....The quality of the
writing is good...The text amply lives up to its commitment to
provide 'mainly...solid basics'."--Canadian
Medical Association Journal
976 pp.; 414 linecuts; 8-1/2 x 11; 0-19-510024-7, 1997 Price: $59.95
Pharmacology for
Chemists
JOSEPH G. CANNON, University of Iowa
An accessible and quick introduction to the scientific
study of drugs, including their composition, uses, and
physiological effects.
New and recent titles of related interest:
288 pp.; 66 figures; 6-1/8 x 9-1/4; 0-8412-3524-4, 1999 Price: $120.00
Oxford Textbook of Clinical
Nephrology
3-Volume Set
Second Edition
Edited by ALEX M. DAVISON, St. James University Hospital,
Leeds, J. STEWART CAMERON, Guy's Hospital, London, JEAN-PIERRE
GRÜNFELD, Hôspital Necker, Paris, DAVID N. S. KERR, Royal
Postgraduate Medical School, London, EBERHARD RITZ, Ruperto Carlo
University, Heidelberg, and CHRISTOPHER G. WINEARLS, Oxford
Radcliffe Hospital, Oxford
The first edition of the Oxford Textbook
of Clinical Nephrology established itself as the leading
clinical reference text for practicing nephrologists worldwide.
The second edition comes five years later, during which time
there have been significant advances in the understanding of the
pathogenesis of renal disease and in therapy. Placing existing
treatment on a firm scientific basis or stopping ineffective or
dangerous treatment is as important as introducing proven new
therapies, and all the contributors have taken this fully into
account.
During the development of the second edition all the first edition chapters were critically reviewed by practising nephrologists and their suggestions have been incorporated to make the text even more practically useful and logically arranged. Expert topic editors in pediatrics, pathology, physiology and pharmacology have checked all relevant sections from their own perspective.
This edition is the only major textbook of
nephrology to be printed in full colour throughout. Reproduction
of the histological and clinical illustrations in their natural
colours reveals their true significance, and there are numerous
new colour illustrations. New chapters cover imaging tactics; the
structural basis of glomerular function; symptomless patient with
abnormal urine; fibrillary nephritis; interstitial disease; and
host factors in the pathogenesis of urinary tract infection. The
sections on acute and chronic renal failure have been reorganized
with new chapters on the Epidemiology of acute renal failure,
Dialysis and haemoperfusion treatment in acute poisoning,
and Genesis of the uraemic syndrome. In addition, the
chapter on Gastrointestinal effects in chronic renal failure
includes a new discussion of the various forms of hepatitis. A
new section on renal failure in special settings includes new
chapters on pregnancy, tropical illness, and the elderly. In the
inherited diseases section there is a new chapter on purine
metabolism, while the structural diseases section features a new
chapter on Medullary sponge kidney. The section on
malignant disease has new chapters on tumours of the bladder and
the prostate. The result is an outstanding up-to-date,
international clinical text which no clinical nephrologist can
afford to be without.
3168 pp.; full color throughout; 0-19-262413-X , 1997 Price: $475.00 / 3 vol. Set
Neuropharmacology
T. W. STONE, University of Glasgow
This concise and fully up-to-date account
of the effects of drugs on the nervous system begins with an
introduction to the fundamental aspects of neuronal function and
synaptic transmission. Subsequent chapters describe the pharmacology
of the neuromuscular junction, the parasympathetic and
sympathetic divisions of the autonomic nervous system, and the
central nervous system. The text provides a full survey of the
nature and localization of neurotransmitters and their pathways;
the molecular biology and subtypes of receptors; and the effects,
side effects, and clinical uses of drugs. Some familiarity with
molecular structures is helpful in understanding the
relationships between drug classes and their action, so this
volume includes molecular structures of most of the compounds
discussed, with an indication of their stereochemistry. Bridging
the disciplines of pharmacology and neuroscience
and bringing together some of the most exciting and challenging
aspects of both subjects, Neuropharmacology is intended
for advanced undergraduate and graduate students in the
biological and medical sciences, as well as a handy reference for
neuroscientists, neurologists, psychiatrists, and psychologists
who use pharmacology in their everyday research
and practice.
148 pp.; 47 linecuts; 0-7167-4510-0, 1995 Price: $24.50 / paper
An Introduction to
Medicinal Chemistry
GRAHAM L. PATRICK, Paisley University
Medicinal chemistry draws on the
disciplines of chemistry, biochemistry, cell biology and pharmacology,
and students new to this subject often have little knowledge of
these fields. This lively, highly illustrated text provides
undergraduate and postgraduate students with an accessible
introduction to medicinal chemistry. It covers basic principles
and background, and then describes the general tactics and
strategies employed in developing an effective drug. Through the
use of numerous examples it highlights both the difficulties
faced by the medicinal chemist and the great power and potential
of rational drug design.
"The author has presented the subject material in a
readable style at a appropriate level of chemical and biological
sophistication....Chemical structures are well and carefully
reproduced, and there many well-drawn diagrams and drawings which
elucidate and complement the chemical and biological concepts
discussed in the narrative."--Journal of Medicinal
Chemistry
352 pp.; 200 illus.; 0-19-855871-6 , 1995 Price: $45.00
Phytochemistry of Plants
Used in Traditional Medicine
Edited by K. HOSTETTMANN, A. MARSTON, M. MAILLARD, and M.
HAMBURGER, Université de Lausanne, Switzerland
As more is discovered about the unique
healing properties of tropical and other medicinal plants,
scientists around the world--from botanists to pharmacists--are
increasingly attempting to isolate the active compounds of
"folk-remedies" common in ethnomedicine. Phytochemistry
of Plants Used in Traditional Medicine provides a sweeping,
interdisciplinary review of the latest advances and trends in the
field. With contributions from an international cast of
scientists, the book details the efforts to study ethnomedicine
scientifically, with topics ranging from biologically active
metabolites found in plants, to new approaches to sickle cell
anemia, to bioactive compounds culled from higher fungi. Students
and researchers in phytochemistry, chemistry, and pharmacology
will all want to read this important addition to
the literature.
"The lectures represent reviews of the latest advances
and trends in the field of active compounds from tropical and
other medicinal plants." --Journal of the American
Chemical Society
"Specific areas addressed are treatments for cancer, HIV,
protozoal disease, inflammatory disease, and sickle cell anemia.
Regions of the world explored in this pursuit are China,
Indonesia, New Guinea, Bolivia, and Panama." --The
American Herb Association Quarterly
"[T]he volume os a useful one, generally well written,
well edited....It will find a useful place on the bookshelves of
all those interested in the chemical constituents of traditional
medicinal plants." --Lloydiana
424 pp.; 122 illus.; 0-19-857775-3, 1995 Price: $145.00
Applied Neuromuscular Pharmacology
Edited by B. J. POLLARD, University of Manchester
This book gives a comprehensive and
practical review of neuromuscular pharmacology.
It covers all aspects of the subject from the discovery and first
clinical use of curare, to the newest drugs and latest
techniques. It is organised by drug function, to ensure that the
book is of PRACTICAL use to both anaesthetists and
pharmacologists. The use of neuromuscular blocking in a variety
of clinical situations is described.
456 pp.; 83 illus.; 0-19-262148-3 , 1994 Price: $135.00
Neurobiology of
Nociceptors
Edited by C. BELMONTE, University of Alicante, and F. CERVERO,
University of Alcala de Henares
This is the first comprehensive review of
all aspects of nociceptor function, including the structure of
nociceptor endings, neurochemistry, and evolutionary
considerations. It deals with the functional properties of
nociceptors innervating different organs and the biophysical
mechanisms underpinning the transduction process in nociceptors.
Sections cover the modification of nociceptor function by nerve
injury and regeneration, as well as its physiopathology. This is
an essential reference for researchers in neuroscience and pharmacology,
and clinicians working in pain management.
550 pp.; 6 color plates, 145 linecuts & halftones;
0-19-852334-3, 1996 Price: $125.00
Bryophytes
Their Chemistry and
Chemical Taxonomy
Edited by H. D. ZINSMEISTER and R. MUES, both at the
University of Saarlandes
Mosses, liverworts, and hornworts produce a
large variety of compounds which exhibit remarkable biological
activity. This book provides the first comprehensive survey of
the chemistry, biology, and pharmacology of
these extraordinary plant groups. Internationally recognized
experts give readers valuable information on all aspects of the
chemistry of bryophytes, including biochemical, botanical,
pharmaceutical, chemotaxonomical, and environmental studies. In
addition, synthetic studies of new natural products found in
bryophytes are covered.
488 pp.; 57 line drawings, 6 halftones; 0-19-857716-8, 1990 Price: $130.00
The Antimicrobial Drugs
WILLIAM B. PRATT and ROBERT FEKETY, both at University of
Michigan Medical School
With the assistance of an eminent clinician
as co-author, Pratt has reworked and expanded his acclaimed text Chemotherapy
of Infection (OUP, 1977). Two very practical chapters have
been added -- 'Use of Antibiotics in Treatment of Bacterial
Infections in Office Practice' and 'Use of Antibiotics in Severe
Bacterial Infections in Hospitalized Patients' -- and the entire
book has been revised and updated. No other book offers such a
thorough discussion of how the body handles antibiotics or
provides a more complete entry (over 3,000 references) to the
literature. This book will be invaluable to medical and graduate
students in chemotherapy, pharmacology, and
infectious disease; infectious disease specialists, clincial
pharmacologists, internists, and primary care physicians.
640 pp.; 85 illus.; 0-19-503561-5, 1986 Price: $35.00 / paper
Pharmacology
in the Practice of Anaesthesia
Edited by LEON KAUFMAN, University College Hospital and St
Mark's Hospital, London, and PETER V. TABERNER, University of
Bristol School of Medical Sciences, UK
Pharmacology in
the Practice of Anaesthesia outlines, in a highly-accessible
manner, the principles of pharmacology as
applied to anaesthesia and intensive care. Anaesthetists are
expected to know not only the pharmacology of
anaesthetic agents, but also the pharmacology of
drugs used in medical disorders and the possibility of drug
interactions and side effects. The book contains introductory
chapters covering the principles which affect the mode of action
of the drug. These are followed by detailed descriptions of
anaesthetic agents and the drugs affecting each body system.
Relevant physiology is included to make the pharmacology
more comprehensible, and key points are highlighted throughout
the text.
The two applied sciences fundamental to anaesthesia are physiology and pharmacology. All trainees need to acquire a thorough grounding in the principles of pharmacology and their application in practice, and pharmacology thus forms a major part of postgraduate examinations, including the Fellowship exams in the UK, and Boards in the Us. This is an up-to-date textbook for trainees in anaesthesia which will also see them through many years of clinical practice.
The authorship involves the unique, active
collaboration between pharmacologists and clinical anaesthetists.
Leon Kaufman is a well-known FFA examiner, and the many
contributors are lecturers or consultants in anaesthesia or
clinical pharmacology.
704 pp.; 203 linecuts; 0-340-55171-2, 1996 Price: $135.00
Human Drug Kinetics
A Course of
Simulated Experiments
includes software
D. INGRAM, St Bartholemew's Hospital Medical School, L.
SAUNDERS, University of London, and S. H. D. JACKSON, St
Bartholemew's Hospital, London
A complete, interactive course covering the
fundamentals of pharmacology, this book/software
teaching package includes an IBM-PC compatible disk which
provides useful and flexible simulations of experiments. This
integrated system is adaptable to many courses in the field, and
is carefully structured to take students step by step thorough
progressively difficult subject matter. The textbook gives
readers information on twenty different drugs. The software
guides students through administering and monitoring the drug in
question, specifying dose according to sex, age, weight, and
height. After the student runs the experiment, the program
provides information in tables, graphs, or disposition diagrams
to help interpret the results. The authors have marshalled a
formidable range and depth of expertise to develop this reliable,
thorough and comprehensive educational tool. The new
pharmacokinetic model on which the simulations are built uses the
experience gained in developing the well-known MacDope model,
making Human Drug Kinetics mathematically sound and
enormously realistic.
282 pp.; disk; 0-19-963039-9, 1989 Price: $225.00
Ecological Chemistry and
Biochemistry of Plant Terpenoids
Edited by J. B. HARBORNE, University of Reading, and F. A.
TOMAS-BARBERAN, CSIC, Murcia, Spain
The plant terpenoids exhibit enormous
structural and functional diversity. They are involved in
regulating plant growth, acting as accessory pigments in
photosynthesis, and attracting animals to plants for pollination
purposes. This is the most up-to-date work on the subject,
authored by a panel of distinguished international experts. It
reviews the chemistry, chemistry, chemotaxonomy,
biochemistry, biosynthesis, physiology, pharmacology, and
toxicology of plant terpenoids. The work will interest plant and
ecological biochemists, and plant scientists.
466 pp.; 101 illus.; 0-19-857739-7, 1991 Price: $125.00
Handbook of Drug
Interactions
LAKSHMAN KARALLIEDDE, United Medical and Dental School of
Guy's and St Thomas, London, and JOHN A. HENRY, Imperial College
School of Medicine, London
Prescribing more than one drug to a patient
raises the possibility of one drug affecting the intensity of
action, duration of action, and the occurance of serious side
effects associated with another drug. This book provides an
easy-to-use, clinically relevant approach to this complex
problem, bringing together information from various sources. For
each drug, a simple at-a-glance table gives an immediate guide to
whether action is increased, decreased, or changed in other ways
by co-administered drugs. These tables are then cross-referenced
to more detailed text that indicates what actions need to be
taken. Mechanisms of interactions and the latest references are
included for those with a particular interest in the subject.
Drugs are grouped according to their clinical use and there is a
minimal use of complicated pharmacology
terminology. The index includes alternative drug names to ensure
relevance around the world.
960 pp.; 0-340-66204-2, 1998 Price: $75.00
Nicotine
Psychopharmacology
Molecular, Cellular,
and Behavioural Aspects
Edited by S. WONNACOTT, University of Bath, M. A. H. RUSSELL,
Institute of Psychiatry, London, and I. P. STOLERMAN, Institute
of Psychiatry, London
This volume provides a comprehensive review
of the pharmacology of nicotine, covering the
more recent contributions from molecular, biochemical,
neurophysiological, and behavioral approaches. In addition to the
well known health effects related to tobacco addiction, readers
will find information on how nicotine mechanisms are involved in
other psychiatric and neurologic disorders such as Alzheimer's
and Parkinson's Disease. The findings presented here represent an
indispensable, up-to-date resource for doctors, researchers, and
addiction therapists.
448 pp.; 79 line drawings, 14 halftones; 0-19-261614-5,
1990 80.00
Sexual Pharmacology
Edited by ALAN J. RILEY, Private Practitioner, MALCOLM PEET,
University of Sheffield, and CATHERINE WILSON, St George's
Hospital Medical School, London
This volume provides a detailed and
comprehensive review of current knowledge concerning the effect
of drugs on sexual function. The first of its kind in its field,
this book will educate doctors on the effects of those drugs
which commonly cause distress to their patients. The drug effects
are discussed in the context of current understanding of the
underlying biochemical and physiological basis of sexuality, and
all chapters written by leading figures in the fields of sexual
medicine and psychopharmacology.
248 pp.; 20 illus.; 0-19-262283-8, 1994 Price: $75.00
Melatonin
Clinical
Perspectives
Edited by ANDREW MILES, University of Wales College of
Cardiff, DAVID R. S. PHILBRICK, University of Manchester College
of Medicine, Manchester, and CHRISTOPHER THOMPSON, Charing Cross
and Westminster Medical School, London
This volume brings together reviews of the
areas of clinical medicine where the pineal gland hormone
melatonin is thought to play an important role. The contributors
discuss the possible role of melatonin in the occurence of
schizophrenia, its effects on human reproductive function, the
circadian system, thyroid function, and sleep, and the pharmacology
of melatonin and antidepressent drugs.
304 pp.; 77 illus.; 0-19-261652-8, 1988 Price: $80.00
Pharmacogenetics
WENDELL W. WEBER, University of Michigan Medical School
Genes are important modifiers of human
response to drugs, hormones, and toxins. Patients and healthy
individuals alike display significant differences in response and
suffer adverse effects as a result of exposure to many
therapeutic agents as well as occupational chemicals. This
introductory book brings together laboratory methods and
epidemiological studies for defining the role of heredity in
human drug response.
The book is divided into two parts. Part I
describes the emergence and broad scope of pharmacogenetics from
an historical viewpoint, as well as the principles of pharmacology
and genetics that are used to evaluate the importance and
molecular genetic basis of pharmacologic/toxicologic mechanisms
of hypersensitivity in humans and experimental animal models.
Part II presents the experimental epidemiologic and clinical
evidence for the genetics, molecular basis and clinical
significance of thirty-three human traits of pharmacogenetic
importance. The author includes an extensive discussion of the
role of recombinant DNA technology. Thus Part II illustrates the
application of the basic principles discussed in Part I to
real-life situations. This book will serve as a handy reference
to phramacists, epidemiologists, and physicians responsible for
the delivery and administration of drugs.
360 pp.; 52 illus.; 6-1/8 x 9-1/4; 0-19-506878-5, 1997 Price:
$59.50
Drugs in Anaesthesia and
Intensive Care
Second Edition
MARTIN SASADA, British Royal Infirmary, UK, and SUE SMITH,
Cheltenham General Hospital, UK
In everyday practice, anesthesiologists can
make use of a wide range of drug treatments, and require readily
available and accessible information on the appropriate drug to
use in any given situation. The first edition of this book proved
an invaluable guide for trainee and practicing specialist in
instructing them on appropriate drug treatments. This new edition
has been fully updated to take into account recent developments
in clinical pharmacology, and includes
information on many new drugs. The book describes the
pharmacokinetics and pharmodynamics of all the drugs commonly
used in anesthesia. The improved layout of the book allows rapid
access to specific information on the properties and
characteristics of 180 different drugs.
416 pp.; 0-19-262872-0, 1990 Price: $39.50
Oral Anticoagulants
Chemical and
Biological Properties and Clinical Applications
Edited by LEON POLLER, University of Manchester, UK, and JACK
HIRSH, Hamilton Civic Hospitals Research Center, Ontario, Canada
Warfarin and related drugs have been used
for over a half a century in orevntion and treatment of
thrombotic disorders. Onlu recently, however, has their clinical
role been firmly established by randomized studies and their
benefit/risk ratio improved by lower dose therapy with
improvement in laboratory monitoring.
Oral Anticoagulants is the first
comprehensive, practical survey of the subject available. An
international team of recognized experts provide detailed
coverage on the mode of action; clinical pharmacodynamics;
magnitude and sources of variability in individual response to
oral anticoagulants; methods of individualizing dosing regiments;
laboratory monitoring; and comparison between the different
currently prescribed oral anticoagulants.
356 pp.; 0-340-55266-2, 1996 Price: $125.00
Dictionary of
Endocrinology and Related Biomedical Sciences
CONSTANCE R. MARTIN, Hunter College and Graduate Center, City
University of New York
The only reference of its kind, the Dictionary
of Endocrinology and Related Biomedical Sciences provides
over 14,000 total entries. Comprehensive descriptions of more
than 200 hormones, neurotransmitters, growth factors, and related
regulators include information on the chemical structures and the
pathways for their biosynthesis, sequestration, release, and
degradation, as well as on physiological functions, mechanisms of
action, receptor subtypes, response elements, agonists and
antagonists, feedback controls, diseases resulting from
dysfunctions, and the actions and side-effects of therapeutic
agents. Additional citations relate to genes involved in or
affecting the functions, associated metabolic pathways, species
and age-related changes in responses, and procedures for
investigating the regulators With information drawn from the most
up-to-date sources, the dictionary not only emphasizes human
endocrinology but offers observations of other vertebrates,
invertebrates, unicellular eukaryotes, prokaryotes, and
non-living in vitro systems. It will be welcomed by
students and researchers in animal physiology, cell physiology,
biochemistry, molecular biology, embryology, immunology,
genetics, and behavioral psychology.
"Martin has created a unique and useful reference source
for endocrinologists, clinicians, and biomedical researchers. Her
dictionary draws together concepts from a variety of fields such
as endocrine physiology, pharmacology,
molecular biology, biochemistry, immunology, and genetics.
Rapidly changing terminology in medicine and related biological
sciences makes this reference best suited for working
specialists. Recommended for medical and research
collections."--Choice
"This is a highly useful, if not actually essential, book
for endocrinologists... One of the most useful features of the
book is that it contains definitions and descriptions of
properties of the myriad organic chemicals that are now used as
agonists, inhibitors, or regulators of physiological processes at
all levels, molecular, cellular, etc.... (illustrated) lavishly
with structural formulae for these chemicals. The talents,
industry,and erudition of the single author of this dictionary
must be admired and complimented."--General and
Comparative Endocrinology
792 pp.; 7 x 10; 0-19-506033-4, 1995 85.00
The Pharmacology
of Alcohol and Alcohol Dependence
Edited by HENRI BEGLEITER and BENJAMIN KISSIN, both at SUNY
Health Science Center at Brooklyn
This is a comprehensive review of the
pharmacological effects of alcohol and the mechanisms underlying
the pathogenesis of alcoholism. The book draws on general pharmacology,
neuropharmacology, and alcohol studies to explore its theme. The
second volume in the ALCOHOL AND ALCOHOLISM series, it focuses on
the pharmacologic mechanisms underlying the development of
alcoholism. The book as a whole gives a comprehensive and
authoritative picture of the complex pharmacologic actions of
alcohol, particularly on the nervous system. For clinicians and
researchers in the field of alcohol and alcoholism, it will serve
as a fundamental reference.
536 pp.; 19 linecuts; 6-1/2 x 9-1/4; 0-19-510094-8, 1996 99.50
Experimental and Clinical
Neurotoxicology
Second Edition
Edited by PETER S. SPENCER, Oregon Health Sciences University,
HERBERT H. SCHAUMBURG, Albert Einstein College of Medicine, and
ALBERT C. LUDOLPH, University of Ulm, Germany
The first edition of Experimental and
Clinical Neurotoxicology published in 1980 rapidly
established itself as the leading reference work on the toxic
effects of chemicals on the nervous system. The second edition,
is thorouly updated and revised. The underlying principles are
discussed in Part I and neurotoxicats are systematically
described in Part II. With the rapid new developments in
neuroscience in recent years and the increased concern about
environmental toxins, the second edition will appeal to a broad
range of professionals among neurologists, toxicologists,
neurobiologists, and specialists in occupational health.
1152 pp.; 27 line illus; 8-1/2 x 11; 0-19-508477-2, 1999 195.00
Principles of Drug
Therapy in Neurology
Edited by MICHAEL V. JOHNSTON, ROBERT L. MACDONOLD, and ANNE
B. YOUNG
Once considered largely untreatable,
neurologic disorders have become the newest frontier for
breakthrough research in pharmacology. Principles
of Drug Therapy in Neurology discusses the latest
investigatinal strategies and theories and how they affect
current clinical practice. The book details the mechanisms,
delivery systems, and efficacy of the latest medication, as the
editors outline a "method" for thinking about the
action of clinically useful drugs, based on modern information
about kinetics, transport to the brain, interaction with
neurotransmitter systems and membrane action, etc. All types of
major neurologic disorders are discussed.
358 pp.; illus.; 0-8036-5031-0, 1192 75.00
Honorable Mention, Assn. of
American Publishers, Outstanding Professional & Scholarly
Titles of 1996--Chemistry. An Outstanding Academic Book of 1997--Choice
Honorable Mention, Assn. of American Publishers, Outstanding
Professional & Scholarly Titles of 1996--Chemistry. An
Outstanding Academic Book of 1997--Choice
The Chemistry of
Mind-Altering Drugs
History, Pharmacology,
and Cultural Context
DANIEL M. PERRINE, Associate Professor of Chemistry, Loyola
College, MD
This fascinating book presents a
scientificlly objective, and thoroughly documented exposition of
the pharmacological and psychological effects of nearly every
known substance that affects human consciousness, from alcohol to
Zopiclone. It also features first-hand accounts and descriptions
of the social, cultural, and religious milieus in which many
psychotropic plants are used, and discusses historical allusions
to many literary and scientific figures who used or wrote of
mind-altering drugs, including Freud, Dickens, Yeats, and Huxley.
Intended for a wide audience of general readers seeking unbiased
information, the book gives an accessible explanation of
drug-receptor interaction and organic chemical structures, as
well as descriptions of the discovery, isolation, and syntheses
of the chemical substances responsible for drug activity. Written
by an experienced chemist, the book nevertheless keeps technical
information to a minimum.
"An appropriate alternative title for this fascinating,
modestly priced volume might be 'Everything You Always Wanted to
Know about Drugs.' The author . . . has left no stone unturned in
making this vade mecum of drugs, for
specialist or layperson alike, as complete as possible . . .
Clearly a labor of love. . . . I heartily recommend this
interesting and informative study not only to chemists and
pharmacologists but also to professionals, students and educators
in the health sciences as well as to science-conscious citizens
concerned with the social and ethical implications of the use of
mind-altering drugs in our society." --George B. Kauffman in
American Scientist
"This book will provide a pleasant suprise for many
readers! . . . I enthusiastically recommend it to anyone with
basic science literacy who wants a good general overview of
psychoactive substances, how they were discovered, and the roles
they play in medicine and in our present culture." --David
E. Nichols in Journal of Medicinal Chemistry
"Mind-altering substances have captivated human beings
through the ages and have certainly been in the forefront of
local, national, and international politics for more than a
century . . . Because this subject holds the interest of such a
disparate group of individuals, it is not an easy task to write a
book on this subject that would appeal to a diverse audience.
Perrine has made a serious attempt to write such a book . . .
Very readable and chocked with information . . . providing rich
descriptions of the psychological and behavioral effects of
mind-altering drugs." --Journal of the American
Chemical Society
500 pp.; 0-8412-3253-9, 1996, 45.00
Addictions
A Comprehensive
Guidebook
Edited by BARBARA S. MCCRADY and ELIZABETH E. EPSTEIN, both at
Rutgers University
Comprehensive coverage
Since the 1970s, mental-health
professionals and clinical researchers have made tremendous
strides in understanding and treating addictions. This volume
surveys the entire field, providing both practitioners and
researchers with up-to-date summaries of key findings and
methods. Ideal for the lab or clinic, the book is divided into
six parts: pharmacology, psychopharmacology, and
pharmacophysiology of addictive substances; definitions and
diagnosis; etiology, maintenance, and course of substance abuse
disorders; case identification, assessment, and treatment
planning; treatments, including disease model, family system,
medical models, and interventions; and issues for specific
populations. The book provides nearly all of the information a
professional needs to treat substance abusers. It can also be
used as a graduate-level textbook on addictions or to prepare for
the American Psychological Association's proficiency
certification exam on psychoactive substance abuse disorders.
672 pp.; 18 line illus; 7 x 10; 0-19-511489-2 1999, 65.00
Inositol Phosphates and
Derivatives
Synthesis,
Biochemistry, and Therapeutic Potential
Edited by ALLEN B. REITZ, R.W. Johnson Pharmaceutical Research
Institute
This new volume examines the synthesis,
biochemistry, and pharmacological evaluation aspects of design
compounds with therapeutic effects. Two overview chapters provide
comprehensive background information on stereochemistry and
nomenclature of inositol phosphates, basic biochemistry,
synthetic challenges, and related pharmacology.
Subsequent chapters describe novel methods of preparation,
including the use of unusual starting materials and mediation by
microorganisms, therapeutic potential and bioactivity, and
structure-activity relationships.
235 pp.; 0-8412-2086-7 1991, 75.00
Immunosuppressive Drugs
Developments in
Anti-Rejection Therapy
Edited by ANGUS W. THOMSON, University of Pittsburgh, and
THOMAS E. STARZL, University of Pittsburgh
This comprehensive new book provides a
state-of-the art review of recent developments in the field of
drugs that suppress the body's immune system in response to a
transplanted organ, thus preventing rejection. With the current
intense interest in these drugs, there is great demand for a book
which covers their basic science, effects and results. This book
is therefore a much needed addition to the available literature
and will be appreciated by all clinicians working in transplant
centres, academic and industrial research scientists, and
advanced students of immunology and pharmacology.
256 pp.; tables, 94 halftones & linecuts; 0-340-56951-4, 1994
95.00
Wylie and
Churchill-Davidson's A Practice of Anaesthesia
Sixth Edition
Edited by THOMAS E. J. HEALY, University of Manchester, UK,
and PETER J. COHEN, University of Pennsylvania Medical Center
Wylie and Churchill-Davidson's A
Practice of Anaesthesia has a superb reputation as a
comprehensive yet readable account of anesthetic practice.
Building on this tradition of excellence, the Sixth Edition of
this classic text has been significantly enlarged and thoroughly
updated. With contributors representing a variety of disciplines,
this book truly represents the multidisciplinary nature of the
specialty. Heavily illustrated and comprising the expertise of
over 100 authorities in the field, this book will be invaluable
to anesthetists who seek a practical approach to anesthesia.
A Practice of Anaesthesia is divided into four main sections. The first covers the history and theories of anesthesia as well as dealing in-depth with fundamental scientific principles. Sections Two and Three examine the impact of disease and patient status on anesthetic practice. They present a comprehensive and up-to-date discussion of the subspecialties of anesthesia and the application of specific pathological conditions, including burns and head injuries. The final section includes thorough discussions of of medico-legal principles, quality assurance, and medical ethics.
Practical, current, and well-illustrated, you
can rely on this timely text for comprehensive guidance on the
full range of practical applications of anesthesia.
"A delight to read. It would be useful to any practicing
anaesthetist....The editors are to be congratulated in producing
an excellent new textbook following the distinguished traditions
of Wylie and Churchill-Davis."--British Journal of
Anaesthesia
1560 pp.; tables, 462 linecuts & halftones; 0-340-55309-X,
1995 150.00
Chromatography of
Pharmaceuticals
Natural, Synthetic, and Recombinant Products
Edited by SATINDER AHUJA
Describes the role of chromatography in the
development of new drugs. Features chapters on the analysis of
natural and recombinant pharmaceutical products. Covers new
techniques such as capillary electrophoresis and a number of
hyphenated techniques that combine liquid chromatography or gas
chromatography with mass spectrometry. Describes such
applications as impurity analysis, chiral separations, metabolic
studies, robotics, and support of biotechnology products. Also
describes trace and ultratrace analyses in a variety of matrices.
211 pp.; 0-8412-2498-6, 1992 70.00
Patents for Chemicals, Pharmaceuticals
and Biotechnology
Fundamentals of Global Law, Practice and Strategy
PHILIP W. GRUBB
This third edition of the acclaimed Patents
for Chemists provides vital updating and much expanded
coverage while retaining the focus upon the relevant technology
and industry practices. The book guides the reader through the
legal and procedural complexities of the British, European,
Japanese and US patent systems, and explains in detail the role
of patent practitioners in maximizing the commercial potential of
their client's or company's innovative products.
Philip Grubb is a European Patent Attorney and
Intellectual Property Counsel at Norvatis, Switzerland.
480 pp.; 12 line illus; 0-19-876520-7, 1999 80.00
Therapeutic Protein and
Peptide Formulation and Delivery
Edited by ZAHRA SHAHROKH, VICTORIA SLUZKY, JEFFREY L. CLELAND,
STEVE J. SHIRE, and THEODORE W. RANDOLPH
This volume reviews protein stability and
the analytical and biophysical characterization of proteins. It
emphasizes drug delivery approaches, especially local delivery
through the skin. Including both academic and industrial
perspectives from such companies as Genentech, Amgen, and Merck,
the book also discusses novel drug delivery polymers and the
development of pharmaceutical protein formulations.
230 pp.; 0-8412-3528-7, 1997 105.00
Computer-Aided Molecular
Design
Applications in
Agrochemicals, Materials, and Pharmaceuticals
Edited by CHARLES H. REYNOLDS, M. KATHARINE HOLLOWAY, and
HAROLD K. COX
Chronicles recent successes in the
application of computer-aided molecular design to the development
of new agrochemicals, materials, and pharmaceuticals.
Provides an overview of many state-of-the-art modeling
techniques, including CoMFA, molecular dynamics, de novo ligand
design, QSAR, molecular orbital methods, and genetic algorithms.
Includes computational studies of pharmacokinetic properties such
as transport and metabolism. Describes modeling of interfacial
phenomena, including organic and inorganic surfaces.
428 pp.; 0-8412-3160-5, 1995 125.00
Tailored Polymeric
Materials for Controlled Delivery Systems
Edited by IAIN MCCULLOCH, Hoechst-Celanese Corporation, and
SHALABY W. SHALABY, Poly-Med Inc.
The use polymeric materials in drug
delivery systems is one of the most promising technologies in
medical, pharmaceutical, and agricultural
science. This volume emphasizes the role of molecular
architecture in the design and synthesis of new chain molecules.
Topics include nanosphere micelles, microspheres, solid implants,
and injectable liquid gel-formers.
336 pp.; 118 linecuts, 3 halftones; 6 x 9; 0-8412-3585-6, 1998
120.00
Polysaccharide
Applications
Cosmetics and Pharmaceuticals
Edited by MAGDA A. EL-NOKALY and HELENA A. SOINI
Polysaccharides are carbohydrates used in a
number of industrial applications, such as as thickeners,
gellants, emulsifiers, and delivery systems of many commercial
products. Research in the area is limited, however, and this book
fills this gap, providing an up-to-date look at polysaccharide
modifications, interactions with surfactants and micelles,
stability, and characterization of polysaccharides.
368 pp.; 127 figures; 6 x 9; 0-8412-3641-0, 1999 135.00
The Engineering of
Chemical Reactions
LANNY D. SCHMIDT, University of Minnesota
Employment opportunities for chemical
engineers are moving away from petroleum and petrochemicals
toward new applications such as materials processing, pharmaceuticals,
and foods. Chemical reactors remain at the center of any chemical
process; they are essential to improving existing processes and
to designing new ones. Today and in the future chemical engineers
must be able to use their knowledge of reactors in combination
with other skills in order to think creatively and strategically
about new processes and growing applications.
The Engineering of Chemical Reactions addresses these issues by focusing on the analysis of chemical reactors while simultaneously providing a description of industrial chemical processes and the strategies by which they operate. Ideal for upper-level undergraduate courses in chemical reactor engineering and kinetics, this text provides a concise, up-to-date alternative to similar texts. In addition to the analysis of simple chemical reactors, it considers more complex situations such as multistage reactors and reactor-separation systems. Energy management and the role of mass transfer in chemical reactors are also integrated into the text.
The evolution of chemical engineering from petroleum refining, through petrochemicals and polymers, to new applications is described so that students can see the relationships between past, present, and future technologies. Applications such as catalytic processes, environmental modeling, biological reactions, reactions involving solids, oxidation, combustion and safety, polymerization, and multiphase reactors are also described.
The text uses a notation of reaction
stoichiometry and reactor mass balances which is kept simple so
that students can see the principles of reactor design without
becoming lost in complex special cases. Numerical methods are
used throughout to consider more complex problems. Worked
examples are given throughout the text, and over 300 homework
problems are included. Both the examples and problems cover
real-world chemistry and kinetics.
560 pp.; 218 linecuts; 7-1/2 x 9-1/4; 0-19-510588-5, 1997 80.00
Irradiation of Polymers
Fundamentals and
Technological Applications
Edited by ROGER L. CLOUGH and SHALABY W. SHALABY
Discusses structural and physiochemical
effects of irradiation and presents techniques to model and
monitor radiation events. Describes the use of radiation as a
sterilization method in the biomedical, pharmaceutical,
and food industries. Examines current topics in the stability and
stabilization of polymers exposed to ionizing radiation. Reviews
advances in the use of radiation with photosensitive metathesis
polymers, chemical amplification, and dry-develop resist
technology.
448 pp.; 0-8412-3377-2, 1996 120.00
Polymeric Delivery
Systems
Properties and
Applications
Edited by MAGDA A. EL-NOKALY, DAVID M. PIATT, and BONNIE A.
CHARPENTIER
Presents recent advances in basic research
and applications of polymeric delivery systems. Examines
preparation and properties of biodegradable and other polymer
delivery systems. Stimulates new ideas for the application of
polymeric drug delivery technology to cosmetics, foods, pharmaceuticals,
and pesticide systems.
420 pp.; 0-8412-2624-5, 1993 120.00
Desk Reference of
Functional Polymers
Syntheses and
Applications
Edited by REZA ARSHADY
Discusses the synthesis, properties, and
current and potential applications of a wide variety of
functional polymers in four major areas: radiation effects and
applications, opolelectronic properties and applications,
chemical and physicochemical applications, and biomedical
applications. Reviews the general synthetic methods for preparing
functional polymers. Examines functional polymers with properties
of interest in such fields as microlithography, photochemistry,
nonlinear optics, electrical conductivity, chemical sensors,
electron and energy transfer processes, polymeric liquid
crystalline networks, chiral liquid crystalline polymers, solar
energy utilization, floculation of minerals, catalysis, polymeric
dental aids, polymer-drug conjugates, biocompatible polymer
surfaces, and drug targeting by functional polymers.
832 pp.; 0-8412-3469-8, 1997 195.00
Polymer Data Handbook
On-line access to
full text available with purchase; instructions in book.
Edited by JAMES E. MARK, University of Cincinnati
This book presents key data on
approximately 200 important polymers currently in industrial use
or under study in industrial or academic research. No other
single source covers so many polymers or offers such a depth of
data.
1040 pp.; 7-1/2 x 9-1/4; 0-19-510789-6, 1999 250.00
| Please direct all inquiries to: orders@leabooks.com |
| Home --- Professional Books --- Medical Sciences-- Pharmacology |
© LEA Book Distributors 1999